Roused by a single drop of blood, Rosie Daniels wakes up to the chilling realisation that her husband is going to kill her. And she takes flight - with his credit card.
Alone in a strange city, Rosie begins to build a new life: she meets Bill Steiner and she finds an odd junk shop painting, 'Rose Madder', which strangely seems to want her as much as she wants it.
But it's hard for Rosie not to keep looking over her shoulder. Rose-maddened and on the rampage, Norman is a corrupt cop with a dog's instinct for tracking people. And he's getting close. Rosie can feel just how close he's getting...